New diagnostic technologies in melanoma and aggressive skin tumors

The introduction of new technologies in oncological diagnosis has had one of its spearheads in aggressive skin tumors. Some, such as melanoma or Merkel cell carcinoma, have gone from being practically incurable at the metastatic stage, to responding dramatically when their weak point is identified. Throughout this course we will review the molecular biology techniques that play an important role in the diagnosis, pharmacogenetic evaluation and follow-up of these patients and we will review the role that artificial intelligence can have in them.

Objectives:

• Know the methodology, applications and limitations of fluorescent in situ hybridization (FISH) and comparative genomic hybridization techniques.
• Understand the mechanisms of functioning of immunotherapy in melanoma, the role of IHC and the methods of monitoring through proteomics.
• Understand the pharmacogenetic evaluation methods and know the characteristics of the two platforms in operation in Spain.
• See the application of the NGS panels useful for melanoma and the liquid biopsy technique for melanoma monitoring.
• See the potential applications of AI in melanoma diagnosis, prognosis and therapy.
• To update the knowledge on the molecular genetics of cutaneous lymphomas, sarcomas and Merkel cell carcinoma.

Enrollment class periods:

• 1st term: from 1/3/2021 to 30/5/2021
• 2nd term: from 1/6/2021 to 29/8/2021
• 3rd term: from 1/9/2021 to 28/11/2021
• 4th term: from 1/12/2021 to 28/2/2022